Tyr142
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Home > Phosphorylation Site Page: > Tyr142  -  CTNNB1 (mouse)

Site Information
AVVNLINyQDDAELA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449044

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
endothelial ( 1 ) , HaCaT (keratinocyte) ( 2 ) , IEC-18 (epithelial) ( 3 ) , keratinocyte-skin ( 2 ) , RWP1 (pancreatic) ( 3 )

Upstream Regulation
Putative in vivo kinases:
Fer (human) ( 3 ) , Fyn (human) ( 3 )
Kinases, in vitro:
Fer (mouse) ( 3 ) , Fyn (mouse) ( 3 )
Treatments:
genistein ( 3 ) , HGF ( 1 ) , UV ( 2 )

Downstream Regulation
Effects of modification on CTNNB1:
molecular association, regulation ( 3 )
Effects of modification on biological processes:
cell adhesion, altered ( 3 )
Inhibit interaction with:
CTNNA1 (mouse) ( 3 )

References 

1

Huang M, et al. (2020) Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Sci Transl Med 12
32102932   Curated Info

2

Jean C, et al. (2009) Epidermal growth factor receptor/beta-catenin/T-cell factor 4/matrix metalloproteinase 1: a new pathway for regulating keratinocyte invasiveness after UVA irradiation. Cancer Res 69, 3291-9
19336574   Curated Info

3

Piedra J, et al. (2003) p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol 23, 2287-97
12640114   Curated Info