Tyr33
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Home > Phosphorylation Site Page: > Tyr33  -  WWOX (mouse)

Site Information
TTKDGWVyYANHTEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449043

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 4 ) , phospho-antibody ( 2 , 3 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 4 , 5 )
Disease tissue studied:
breast cancer ( 4 ) , leukemia ( 1 ) , T cell leukemia ( 1 ) , neuroblastoma ( 4 ) , fibrosarcoma of soft tissue ( 5 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 3 , 4 ) , COS7 (fibroblast) ( 2 ) , Jurkat (T lymphocyte) ( 1 ) , L929 (fibroblast) ( 5 ) , MDA-MB-231 (breast cell) ( 4 ) , MOLT-4 (T lymphocyte) ( 1 ) , SKNSH (neural crest) ( 4 ) , T-ALL (T lymphocyte) ( 1 ) , yeast cell ( 4 )

Upstream Regulation
Treatments:
A23187 ( 1 ) , anisomycin ( 5 ) , cold_shock ( 2 ) , phorbol_ester ( 1 ) , staurosporine ( 3 ) , UV ( 2 , 5 )

Downstream Regulation
Effects of modification on WWOX:
molecular association, regulation ( 1 , 4 )
Effects of modification on biological processes:
apoptosis, induced ( 4 )
Induce interaction with:
ERK1 (mouse) ( 1 ) , ERK2 (mouse) ( 1 ) , IkB-alpha (mouse) ( 1 ) , ZFRA (mouse) ( 4 )

References 

1

Huang SS, et al. (2016) Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation. J Biol Chem 291, 17319-31
27339895   Curated Info

2

Chen SJ, et al. (2015) UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures. Oncotarget 6, 8007-18
25779665   Curated Info

3

Hsu LJ, et al. (2008) Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria. Cell Signal 20, 1303-12
18403180   Curated Info

4

Hong Q, et al. (2007) Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response. BMC Mol Biol 8, 50
17567906   Curated Info

5

Chang NS, Doherty J, Ensign A (2003) JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. J Biol Chem 278, 9195-202
12514174   Curated Info

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