Tyr23
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Home > Phosphorylation Site Page: > Tyr23  -  PIN1 (human)

Site Information
sRSSGRVyYFNHITN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 473849
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 ) , mass spectrometry ( 1 , 2 , 3 , 4 ) , western blotting ( 5 )
Disease tissue studied:
gastric cancer ( 1 , 3 ) , gastric carcinoma ( 1 ) , leukemia ( 4 ) , acute myelogenous leukemia ( 4 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on PIN1:
molecular association, regulation ( 5 , 6 )
Effects of modification on biological processes:
cell cycle regulation ( 5 )
Induce interaction with:
KIF20B (human) ( 5 )

References 

1

Possemato A (2011) CST Curation Set: 11913; Year: 2011; Biosample/Treatment: cell line, MKN-45/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Gu TL, et al. (2007) A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood 110, 323-33
17360941   Curated Info

3

Guo A (2006) CST Curation Set: 1643; Year: 2006; Biosample/Treatment: cell line, SNU-16/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Gu T (2006) CST Curation Set: 1557; Year: 2006; Biosample/Treatment: cell line, MKPL-1/untreated; Disease: acute myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

5

Kamimoto T, et al. (2001) Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. J Biol Chem 276, 37520-8
11470801   Curated Info

6

Lu PJ, Zhou XZ, Shen M, Lu KP (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325-8
10037602   Curated Info