Ser388
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Home > Phosphorylation Site Page: > Ser388  -  IRF3 (mouse)

Site Information
KTVDLHIsNSQPISL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449028

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , immunoprecipitation ( 9 ) , mass spectrometry ( 9 ) , mutation of modification site ( 9 ) , phospho-antibody ( 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ) , western blotting ( 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 9 ) , bone marrow ( 6 ) , dendritic cell ( 6 ) , HEK293T (epithelial) ( 10 ) , macrophage-bone marrow ( 5 , 8 , 10 ) , macrophage-peritoneum ( 4 , 12 ) , MEF (fibroblast) ( 9 , 11 , 13 ) , microglia ( 7 ) , MMTV-PyMT (breast cell) ( 3 )

Upstream Regulation
Regulatory protein:
AIM2 (human) ( 7 ) , ARHGEF2 (mouse) ( 10 ) , IFNB1 (mouse) ( 8 ) , MAVS (human) ( 6 ) , MAVS (mouse) ( 10 ) , PARP9 (human) ( 6 ) , RIOK3 (human) ( 4 ) , TGM2 (mouse) ( 5 )
Putative in vivo kinases:
TBK1 (mouse) ( 5 )
Treatments:
bacterial infection ( 5 ) , BX795 ( 11 ) , cGAMP ( 5 ) , double-stranded_RNA ( 10 ) , LPS ( 8 , 10 , 11 , 12 ) , NU7441 ( 7 ) , poly(dA:dT) ( 7 ) , poly(I-C) ( 4 ) , siRNA ( 7 ) , virus infection ( 4 , 5 , 6 ) , Z-Don ( 5 ) , Z-VAD-FMK ( 8 )

Downstream Regulation
Effects of modification on IRF3:
enzymatic activity, induced ( 3 ) , intracellular localization ( 3 , 5 )
Effects of modification on biological processes:
transcription, induced ( 4 , 5 , 10 )

References 

1

Patel SJ, et al. (2022) Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of . Sci Transl Med 14, eabh3831
35320000   Curated Info

2

Liu Z, et al. (2022) Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity. Proc Natl Acad Sci U S A 119
34969857   Curated Info

3

Wang YL, et al. (2021) Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Rep 36, 109537
34433039   Curated Info

4

Shen Y, et al. (2021) Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Cell Rep 35, 109272
34161773   Curated Info

5

Occhigrossi L, et al. (2021) Transglutaminase 2 Regulates Innate Immunity by Modulating the STING/TBK1/IRF3 Axis. J Immunol 206, 2420-2429
33941660   Curated Info

6

Xing J, et al. (2021) Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells. Nat Commun 12, 2681
33976210   Curated Info

7

Ma C, et al. (2021) AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis. J Exp Med 218
33710283   Curated Info

8

Sarhan J, et al. (2018) Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death Differ
29786074   Curated Info

9

Li S, et al. (2016) The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nat Immunol 17, 241-9
26692175   Curated Info

10

Chiang HS, et al. (2014) GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol 15, 63-71
24270516   Curated Info

11

Wild P, et al. (2011) Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 333, 228-33
21617041   Curated Info

12

Liu X, et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12, 416-24
21441935   Curated Info

13

Xie X, et al. (2011) IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A 108, 6474-9
21464307   Curated Info