Ser388
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Home > Phosphorylation Site Page: > Ser388  -  IRF3 (mouse)

Site Information
KTVDLHIsNSQPISL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449028

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , HEK293T (epithelial) ( 3 ) , macrophage-bone marrow ( 1 , 3 ) , macrophage-peritoneum ( 5 ) , MEF (fibroblast) ( 2 , 4 , 6 )

Upstream Regulation
Regulatory protein:
ARHGEF2 (mouse) ( 3 ) , IFNB1 (mouse) ( 1 )
Treatments:
BX795 ( 4 ) , double-stranded_RNA ( 3 ) , LPS ( 1 , 3 , 4 , 5 ) , Z-VAD-FMK ( 1 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 3 )

References 

1

Sarhan J, et al. (2018) Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death Differ
29786074   Curated Info

2

Li S, et al. (2016) The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nat Immunol 17, 241-9
26692175   Curated Info

3

Chiang HS, et al. (2014) GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol 15, 63-71
24270516   Curated Info

4

Wild P, et al. (2011) Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 333, 228-33
21617041   Curated Info

5

Liu X, et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12, 416-24
21441935   Curated Info

6

Xie X, et al. (2011) IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A 108, 6474-9
21464307   Curated Info