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Site Information |
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KTVDLHIsNSQPISL SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 449028 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
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Downstream Regulation | |
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Effects of modification on IRF3: | |
Effects of modification on biological processes: |
References | |
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Patel SJ, et al. (2022) Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of . Sci Transl Med 14, eabh3831
35320000 Curated Info |
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Liu Z, et al. (2022) Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity. Proc Natl Acad Sci U S A 119
34969857 Curated Info |
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Wang YL, et al. (2021) Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Rep 36, 109537
34433039 Curated Info |
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Shen Y, et al. (2021) Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation. Cell Rep 35, 109272
34161773 Curated Info |
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Occhigrossi L, et al. (2021) Transglutaminase 2 Regulates Innate Immunity by Modulating the STING/TBK1/IRF3 Axis. J Immunol 206, 2420-2429
33941660 Curated Info |
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Xing J, et al. (2021) Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells. Nat Commun 12, 2681
33976210 Curated Info |
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Ma C, et al. (2021) AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis. J Exp Med 218
33710283 Curated Info |
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Sarhan J, et al. (2018) Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death Differ
29786074 Curated Info |
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Li S, et al. (2016) The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nat Immunol 17, 241-9
26692175 Curated Info |
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Chiang HS, et al. (2014) GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol 15, 63-71
24270516 Curated Info |
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Wild P, et al. (2011) Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 333, 228-33
21617041 Curated Info |
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Liu X, et al. (2011) Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol 12, 416-24
21441935 Curated Info |
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Xie X, et al. (2011) IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A 108, 6474-9
21464307 Curated Info |