Thr406
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr406  -  TRPV1 (rat)

Site Information
IAYSSSEtPNRHDML   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 473576

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , CHO (fibroblast) ( 1 ) , dorsal root ganglia ( 3 ) , neuron ( 2 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (rat) ( 3 )
Kinases, in vitro:
CDK5 (rat) ( 3 )
Treatments:
peptide inhibitor ( 2 ) , seliciclib ( 3 )

Downstream Regulation
Effects of modification on TRPV1:
activity, inhibited ( 1 ) , intracellular localization ( 2 ) , molecular association, regulation ( 2 ) , phosphorylation ( 3 ) , protein conformation ( 1 ) , receptor desensitization, inhibited ( 1 )
Induce interaction with:
KIF13B (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
hyperalgesia ( 2 )

References 

1

Jendryke T, et al. (2016) TRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociception. Sci Rep 6, 22007
26902776   Curated Info

2

Liu J, Du J, Yang Y, Wang Y (2015) Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol 273, 253-62
26376215   Curated Info

3

Pareek TK, et al. (2007) Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A 104, 660-5
17194758   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.