Tyr23
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Home > Phosphorylation Site Page: > Tyr23  -  fascin (human)

Site Information
LINCGNKyLTAEAFG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6157484

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
esophageal cancer ( 1 ) , esophageal carcinoma ( 1 ) , gastric cancer ( 3 ) , gastric carcinoma ( 3 ) , cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
Su11274 ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, inhibited ( 1 ) , cell motility, inhibited ( 1 ) , cytoskeletal reorganization ( 1 )

References 

1

Zeng FM, et al. (2017) Fascin phosphorylation sites combine to regulate esophageal squamous cancer cell behavior. Amino Acids 49, 943-955
28251354   Curated Info

2

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

3

Moritz A, et al. (2010) Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases. Sci Signal 3, ra64
20736484   Curated Info

4

Moritz A (2008) CST Curation Set: 5771; Year: 2008; Biosample/Treatment: cell line, MKN-45/Su11274; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info