Lys289
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Home > Sumoylation Site Page: > Lys289  -  NR5A2 (mouse)

Site Information
HFPSRAIkSEYPDPY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6124701

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , mutation of modification site ( 2 , 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
COS7 (fibroblast) ( 3 ) , granulosa ( 3 ) , liver ( 2 )

Downstream Regulation
Effects of modification on NR5A2:
intracellular localization ( 3 ) , protein processing ( 2 )
Effects of modification on biological processes:
transcription, inhibited ( 3 )

References 

1

Lumpkin RJ, et al. (2017) Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun 8, 1171
29079793   Curated Info

2

Stein S, et al. (2017) Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. J Clin Invest 127, 583-592
28094767   Curated Info

3

Yang FM, et al. (2009) Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells. FEBS J 276, 425-36
19125815   Curated Info