Tyr281

Site Information
RELAVQIyEEARKFS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 473349
Available spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 )
Disease tissue studied:	gastric cancer ( 1 , 3 ) , leukemia ( 6 ) , chronic myelogenous leukemia ( 6 ) , non-small cell lung cancer ( 2 , 4 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:	GIST-T1 (gastrointestinal) ( 1 ) , K562 (erythroid) ( 6 , 7 , 8 ) , MKN-45 (gastric) ( 3 ) , NCI-H2228 (pulmonary) ( 2 ) , NCI-H3255 (pulmonary) ( 4 ) , P116 (T lymphocyte) [ZAP70 (human), homozygous knockout] ( 5 ) , P116 (T lymphocyte) ( 5 )

References
1	Takahashi T, et al. (2013) New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis. Int J Cancer 133, 2737-43 23716303 Curated Info
2	Rikova K (2013) CST Curation Set: 18449; Year: 2012; Biosample/Treatment: cell line, H2228/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine (P-Tyr-1000) MultiMab(TM) Rabbit mAb mix Cat#: 8954 Curated Info
3	Rikova K (2012) CST Curation Set: 16137; Year: 2012; Biosample/Treatment: cell line, MKN45/crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine (P-Tyr-1000) MultiMab(TM) Rabbit mAb mix Cat#: 8954 Curated Info
4	Rikova K (2012) CST Curation Set: 16138; Year: 2012; Biosample/Treatment: cell line, H3255/iressa; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine (P-Tyr-1000) MultiMab(TM) Rabbit mAb mix Cat#: 8954 Curated Info
5	Nguyen V, et al. (2009) A new approach for quantitative phosphoproteomic dissection of signaling pathways applied to T cell receptor activation. Mol Cell Proteomics 8, 2418-31 19605366 Curated Info
6	Moritz A (2007) CST Curation Set: 2405; Year: 2007; Biosample/Treatment: cell line, K562/-; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
7	Moritz A (2006) CST Curation Set: 1970; Year: 2006; Biosample1/Treatment/Isotope: cell line, K562/none/L, Biosample2/Treatment/Isotope: cell line, K562/none/H; Disease: chronic myelogenous leukemia; SILAC: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
8	Moritz A (2006) CST Curation Set: 3182; Year: 2006; Biosample1/Treatment/Isotope: cell line, K562/none/L, Biosample2/Treatment/Isotope: cell line, K562/none/H; Disease: chronic myelogenous leukemia; SILAC: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
9	MS Claus Jorgensen dataset-Toronto Curated Info