Tyr1194

Site Information
QVAkGMkyLASKkFV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 473312

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:	multiple myeloma ( 1 )
Relevant cell line - cell type - tissue:	BTI-Tn-5B1-4 ( 2 ) , KMS-11 (B lymphocyte) ( 1 )

Downstream Regulation
Effects of modification on Met:	enzymatic activity, induced ( 2 ) , protein conformation ( 2 )

References
1	Gu T (2006) CST Curation Set: 1728; Year: 2006; Biosample/Treatment: cell line, KMS-11/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	Schiering N, et al. (2003) Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A 100, 12654-9 14559966 Curated Info