Ser115
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Home > Phosphorylation Site Page: > Ser115  -  Snail1 (human)

Site Information
PAPssFSsTSVsSLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6097707

In vivo Characterization
Methods used to characterize site in vivo:
microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 ) , MCF-7 (breast cell) ( 1 , 2 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 2 )
Kinases, in vitro:
GSK3B (human) ( 1 )
Putative upstream phosphatases:
CTDSP1 (human) ( 1 )
Phosphatases, in vitro:
CTDSP1 (human) ( 1 )

Downstream Regulation
Effects of modification on Snail1:
intracellular localization ( 1 , 2 )
Effects of modification on biological processes:
cell motility, altered ( 1 ) , transcription, altered ( 1 )

References 

1

Wu Y, Evers BM, Zhou BP (2009) Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation. J Biol Chem 284, 640-8
19004823   Curated Info

2

Zhou BP, et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6, 931-40
15448698   Curated Info

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