Ser100
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Home > Phosphorylation Site Page: > Ser100  -  Snail1 (human)

Site Information
DEDsGKGsQPPsPPs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6097704

In vivo Characterization
Methods used to characterize site in vivo:
microscopy-colocalization with upstream kinase ( 4 ) , mutation of modification site ( 1 , 4 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 1 , 3 , 4 )
Disease tissue studied:
breast cancer ( 3 , 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 4 )
Kinases, in vitro:
GSK3B (human) ( 2 , 3 )
Putative upstream phosphatases:
CTDSP1 (human) ( 3 )
Phosphatases, in vitro:
CTDSP1 (human) ( 3 )

Downstream Regulation
Effects of modification on Snail1:
intracellular localization ( 3 ) , protein degradation ( 3 , 4 ) , ubiquitination ( 4 )
Effects of modification on biological processes:
cell motility, altered ( 3 ) , transcription, altered ( 3 )
Induce interaction with:
FBW1B (human) ( 4 )

References 

1

Boohaker RJ, Cui X, Stackhouse M, Xu B (2013) ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity. Radiother Oncol 108, 403-8
23891091   Curated Info

2

Xu Y, et al. (2010) Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Oncogene 29, 3124-33
20305697   Curated Info

3

Wu Y, Evers BM, Zhou BP (2009) Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation. J Biol Chem 284, 640-8
19004823   Curated Info

4

Zhou BP, et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6, 931-40
15448698   Curated Info