Tyr39

Site Information
KTKEGVMyVGAKtKE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 473114
Available spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:	breast cancer ( 3 ) , lung cancer ( 1 , 4 , 5 ) , non-small cell lung cancer ( 4 ) , non-small cell lung adenocarcinoma ( 1 , 4 )
Relevant cell line - cell type - tissue:	Cal-12T (pulmonary) ( 4 ) , HCC44 (pulmonary) ( 4 ) , HeLa (cervical) ( 2 ) , K562 (erythroid) ( 6 ) , KPL-4 (breast cell) ( 3 ) , lung ( 4 ) , NCI-H1437 (pulmonary) ( 4 ) , NCI-H1666 (pulmonary) ( 4 ) , NCI-H2405 (pulmonary) ( 4 ) , NCI-H292 (pulmonary) ( 5 ) , PC9 (pulmonary) ( 1 )

Upstream Regulation
Treatments:	erlotinib ( 3 )

References
1	Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622 25814448 Curated Info
2	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
3	Tzouros M, et al. (2013) Development of a 5-plex SILAC method tuned for the quantitation of tyrosine phosphorylation dynamics. Mol Cell Proteomics 12, 3339-49 23882028 Curated Info
4	Rikova K, Hall B (2013) CST Curation Set: 20741, 21168, 30173, 30174, 30175; Year: 2013; Biosample/Treatment: cell line, H1666, CAL-12T, H2405, HCC44, H1437; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P Curated Info
5	Li J, et al. (2010) A chemical and phosphoproteomic characterization of dasatinib action in lung cancer. Nat Chem Biol 6, 291-9 20190765 Curated Info
6	Moritz A (2007) CST Curation Set: 2410; Year: 2007; Biosample/Treatment: cell line, K562/-; Disease: chronic myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info