Tyr99
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Home > Phosphorylation Site Page: > Tyr99  -  MDM4 (human)

Site Information
VkDPsPLyDMLRKNL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6039500

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
breast cancer ( 3 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 3 )
Treatments:
adriamycin ( 3 ) , H2O2 ( 3 ) , vanadate ( 3 )

Downstream Regulation
Effects of modification on MDM4:
molecular association, regulation ( 1 , 2 , 3 ) , phosphorylation ( 3 ) , protein conformation ( 1 ) , protein stabilization ( 2 )
Inhibit interaction with:
53BP1 (human) ( 1 ) , p53 (human) ( 2 , 3 )

References 

1

Chan JV, et al. (2017) Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53. Oncotarget 8, 112825-112840
29348869   Curated Info

2

Chen X, et al. (2016) Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene 35, 1919-25
26148237   Curated Info

3

Zuckerman V, et al. (2009) c-Abl phosphorylates Hdmx and regulates its interaction with p53. J Biol Chem 284, 4031-9
19075013   Curated Info