Tyr102
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Home > Phosphorylation Site Page: > Tyr102  -  WASP (human)

Site Information
LLWEQELySQLVYST   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 60110900

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lymphoma ( 1 ) , anaplastic large cell lymphoma ( 1 ) , T cell lymphoma ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , Karpas-299 (T lymphocyte) ( 1 ) , SUP-M2 (T lymphocyte) ( 1 )

Upstream Regulation
Kinases, in vitro:
NPM-ALK (human) ( 1 )

Downstream Regulation
Effects of modification on WASP:
molecular association, regulation ( 1 ) , protein degradation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )
Inhibit interaction with:
WIPF1 (human) ( 1 )

References 

1

Murga-Zamalloa CA, et al. (2017) NPM-ALK phosphorylates WASp Y102 and contributes to oncogenesis of anaplastic large cell lymphoma. Oncogene 36, 2085-2094
27694894   Curated Info

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