Thr522
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Home > Phosphorylation Site Page: > Thr522  -  SIRT1 (mouse)

Site Information
HLSELPPtPLHIsED   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6006905

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
bone cancer ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 2 ) , liver ( 1 ) , MEF (fibroblast) ( 1 , 2 ) , U2OS (bone cell) ( 2 )

Upstream Regulation
Putative in vivo kinases:
DYRK1A (human) ( 2 ) , DYRK3 (human) ( 2 )
Kinases, in vitro:
DYRK1A (human) ( 2 ) , DYRK3 (human) ( 2 )
Treatments:
heat_shock ( 2 ) , high-fat diet ( 1 )

Downstream Regulation
Effects of modification on SIRT1:
acetylation ( 2 ) , enzymatic activity, induced ( 1 , 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
apoptosis, altered ( 2 ) , cell differentiation, inhibited ( 1 )
Inhibit interaction with:
p53 (human) ( 2 )

References 

1

Lu J, et al. (2017) The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice. EMBO Rep 18, 841-857
28364022   Curated Info

2

Guo X, Williams JG, Schug TT, Li X (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem 285, 13223-32
20167603   Curated Info