Ser164
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.1.1
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser164  -  SIRT1 (mouse)

Site Information
DDRTSHAsSSDWTPR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6006904

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 ) , hepatocyte-liver ( 1 ) , liver ( 1 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (mouse) ( 1 )
Kinases, in vitro:
CK2A1 (mouse) ( 1 )
Treatments:
high-fat diet ( 1 ) , IL-1b ( 1 )

Downstream Regulation
Effects of modification on SIRT1:
enzymatic activity, inhibited ( 1 ) , intracellular localization ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
NAFLD ( 1 )

References 

1

Choi SE, et al. (2017) Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. Mol Cell Biol 37
28533219   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2019 Cell Signaling Technology, Inc.