Ser164
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Home > Phosphorylation Site Page: > Ser164  -  SIRT1 (mouse)

Site Information
DDRTSHAsSSDWTPR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 6006904

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 ) , hepatocyte-liver ( 2 ) , liver ( 2 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (mouse) ( 2 )
Kinases, in vitro:
CK2A1 (mouse) ( 2 )
Treatments:
high-fat diet ( 2 ) , IL-1b ( 2 )

Downstream Regulation
Effects of modification on SIRT1:
enzymatic activity, inhibited ( 2 ) , intracellular localization ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
NAFLD ( 2 )

References 

1

Yao JY, et al. (2021) Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling. Acta Pharmacol Sin
34188177   Curated Info

2

Choi SE, et al. (2017) Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. Mol Cell Biol 37
28533219   Curated Info