Ser729
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Home > Phosphorylation Site Page: > Ser729  -  PKCE (rat)

Site Information
QEEFKGFsYFGEDLM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448789

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , phospho-antibody ( 3 , 4 , 5 , 6 ) , western blotting ( 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , 'muscle, skeletal' ( 6 ) , heart ( 2 , 3 , 4 , 5 ) , intestine ( 2 ) , kidney ( 2 ) , liver ( 2 ) , lung ( 2 ) , muscle ( 2 ) , pancreas ( 2 ) , spleen ( 2 ) , testis ( 2 ) , thymus ( 2 )

Upstream Regulation
Treatments:
meal feeding ( 5 , 6 ) , streptozotocin ( 3 )

Downstream Regulation
Effects of modification on PKCE:
enzymatic activity, induced ( 6 ) , intracellular localization ( 6 )

References 

1

Lin G, Brownsey RW, Macleod KM (2014) Complex regulation of PKCĪ²2 and PDK-1/AKT by ROCK2 in diabetic heart. PLoS One 9, e86520
24466133   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Lin G, Liu Y, MacLeod KM (2009) Regulation of muscle creatine kinase by phosphorylation in normal and diabetic hearts. Cell Mol Life Sci 66, 135-44
18979206   Curated Info

4

Shinmura K, Nagai M, Tamaki K, Bolli R (2008) Loss of ischaemic preconditioning in ovariectomized rat hearts: possible involvement of impaired protein kinase C epsilon phosphorylation. Cardiovasc Res 79, 387-94
18390563   Curated Info

5

Vary TC, Lynch CJ (2006) Meal feeding stimulates phosphorylation of multiple effector proteins regulating protein synthetic processes in rat hearts. J Nutr 136, 2284-90
16920842   Curated Info

6

Vary TC, Goodman S, Kilpatrick LE, Lynch CJ (2005) Nutrient regulation of PKCepsilon is mediated by leucine, not insulin, in skeletal muscle. Am J Physiol Endocrinol Metab 289, E684-94
15886222   Curated Info