Tyr304
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Home > Phosphorylation Site Page: > Tyr304  -  DOK2 (mouse)

Site Information
PGAPEGEyAVPFDTV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448880

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
LYN (mouse) ( 3 )

Downstream Regulation
Effects of modification on DOK2:
molecular association, regulation ( 1 , 2 , 3 )
Effects of modification on biological processes:
cell differentiation, altered ( 1 ) , cell growth, altered ( 1 )
Induce interaction with:
RASA1 (human) ( 2 ) , RASA1 (mouse) ( 1 , 3 )

References 

1

Gugasyan R, et al. (2002) Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites. J Cell Biol 158, 115-25
12093790   Curated Info

2

Jones N, Dumont DJ (1999) Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation. Curr Biol 9, 1057-60
10508618   Curated Info

3

Lock P, Casagranda F, Dunn AR (1999) Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck. J Biol Chem 274, 22775-84
10428862   Curated Info