Lys166

Site Information
FSCKYCDkEYVSLGA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 59171804

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 1 , 2 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , peptide sequencing ( 1 ) , western blotting ( 1 )
Disease tissue studied:	breast cancer ( 1 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 1 , 2 ) , MCF-7 (breast cell) ( 1 ) , SUM159 (breast cell) ( 1 )

Downstream Regulation
Effects of modification on Snail2:	protein stabilization ( 1 )
Effects of modification on biological processes:	cell motility, induced ( 1 )

References
1	Dai X, et al. (2021) CBP-mediated Slug acetylation stabilizes Slug and promotes EMT and migration of breast cancer cells. Sci China Life Sci 64, 563-574 32737855 Curated Info
2	Zhou W, et al. (2016) The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer. Cell Rep 17, 1302-1317 27783945 Curated Info