Tyr1228
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Home > Phosphorylation Site Page: > Tyr1228  -  Met (mouse)

Site Information
FGLArDMyDKEyysV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448866

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
C2C12 (myoblast) ( 2 ) , neuron ( 1 )

Upstream Regulation
Regulatory protein:
HGF (human) ( 1 )

Downstream Regulation
Effects of modification on Met:
enzymatic activity, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
ALS ( 1 )

References 

1

Kadoyama K, et al. (2009) Disease-dependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS. Neurosci Res 65, 194-200
19595710   Curated Info

2

Possemato A (2008) CST Curation Set: 4929; Year: 2008; Biosample/Treatment: cell line, C2C12/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Gu T (2006) CST Curation Set: 1519; Year: 2006; Biosample/Treatment: cell line, Thom/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info