Tyr112
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Home > Phosphorylation Site Page: > Tyr112  -  CTNND1 (mouse)

Site Information
PGQIVETyTEEDPEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 472275

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , phosphoamino acid analysis ( 2 ) , phosphopeptide mapping ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , COS (fibroblast) ( 2 ) , RWP1 (pancreatic) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src iso1 (mouse) ( 2 )
Kinases, in vitro:
Fyn (human) ( 1 ) , Src iso1 (mouse) ( 2 )

Downstream Regulation
Effects of modification on CTNND1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )
Induce interaction with:
CDH1 (human) ( 1 )
Inhibit interaction with:
RHOA (human) ( 1 )

References 

1

Castaño J, et al. (2007) Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA. Mol Cell Biol 27, 1745-57
17194753   Curated Info

2

Mariner DJ, et al. (2001) Identification of Src phosphorylation sites in the catenin p120ctn. J Biol Chem 276, 28006-13
11382764   Curated Info

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