Lys14
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Home > Mono-methylation Site Page: > Lys14  -  Akt1 (human)

Site Information
VkEGWLHkRGEYIkT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 58948913

In vivo Characterization
Methods used to characterize site in vivo:
modification-specific antibody ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
BCI-121 ( 1 )

Downstream Regulation
Effects of modification on Akt1:
activity, induced ( 1 ) , intracellular localization ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )

References 

1

Yoshioka Y, et al. (2016) SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1. Oncotarget 7, 75023-75037
27626683   Curated Info