Ser165
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Home > Phosphorylation Site Page: > Ser165  -  NFAT4 (human)

Site Information
RESSLsPsPASSISs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448858

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , electrophoretic mobility shift ( 4 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 4 ) , phosphopeptide mapping ( 4 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
JNK2 (human) ( 4 )
Kinases, in vitro:
CK1A (rat) ( 3 ) , JNK2 (human) ( 4 )

Downstream Regulation
Effects of modification on NFAT4:
intracellular localization ( 4 )
Effects of modification on biological processes:
transcription, inhibited ( 4 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

3

Marin O, et al. (2002) Structural features underlying the multisite phosphorylation of the A domain of the NF-AT4 transcription factor by protein kinase CK1. Biochemistry 41, 618-27
11781102   Curated Info

4

Chow CW, et al. (1997) Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278, 1638-41
9374467   Curated Info