Tyr763
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Home > Phosphorylation Site Page: > Tyr763  -  PDGFRB (human)

Site Information
DMKGDVKyADIESSN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448850

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 5 ) , [32P] bio-synthetic labeling ( 5 , 6 ) , immunoprecipitation ( 7 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 , 4 , 6 , 7 ) , peptide sequencing ( 6 ) , phospho-antibody ( 5 , 6 ) , phosphoamino acid analysis ( 6 ) , phosphopeptide mapping ( 5 , 6 ) , western blotting ( 7 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , epithelial ( 7 ) , Jurkat (T lymphocyte) ( 2 ) , PAE (endothelial) ( 1 , 4 , 5 , 6 )

Upstream Regulation
Putative in vivo kinases:
PDGFRB (human) ( 5 , 6 )
Putative upstream phosphatases:
PTPRJ (human) ( 5 )
Treatments:
PDGF ( 5 , 6 , 7 )

Downstream Regulation
Effects of modification on PDGFRB:
molecular association, regulation ( 3 , 4 , 6 )
Induce interaction with:
SHP-2 (human) ( 3 , 4 , 6 )

References 

1

Lennartsson J, et al. (2010) Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis. Cell Signal 22, 955-60
20138986   Curated Info

2

Possemato A (2008) CST Curation Set: 5316; Year: 2008; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

3

Mitchell D, et al. (2007) The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases. J Biol Chem 282, 15606-18
17403678   Curated Info

4

Ekman S, et al. (2002) SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor. Oncogene 21, 1870-5
11896619   Curated Info

5

Kovalenko M, et al. (2000) Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1. J Biol Chem 275, 16219-26
10821867   Curated Info

6

Rönnstrand L, et al. (1999) SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis. Oncogene 18, 3696-702
10391677   Curated Info

7

Kashishian A, Kazlauskas A, Cooper JA (1992) Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J 11, 1373-82
1314164   Curated Info