Ser139
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Site Information
GkkAtQAsQEy____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448841
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 208 , 210 ) , [32P] ATP in vitro ( 57 ) , [32P] bio-synthetic labeling ( 210 ) , electrophoretic mobility shift ( 210 ) , flow cytometry ( 13 , 14 , 121 , 131 , 151 ) , immunoassay ( 23 , 42 ) , immunoprecipitation ( 6 , 8 , 13 , 14 , 22 , 88 , 96 , 117 , 186 ) , mass spectrometry ( 9 , 26 , 36 , 37 , 43 , 44 , 46 , 47 , 53 , 54 , 55 , 58 , 59 , 60 , 61 , 62 , 64 , 66 , 75 , 76 , 77 , 78 , 80 , 81 , 82 , 83 , 84 , 85 , 90 , 91 , 96 , 97 , 99 , 101 , 104 , 113 , 124 , 125 , 138 , 139 , 154 , 161 ) , microscopy-colocalization with upstream kinase ( 105 , 130 , 150 ) , mutation of modification site ( 4 , 6 , 13 , 22 , 96 , 102 , 142 , 143 , 180 , 187 , 192 , 204 ) , phospho-antibody ( 3 , 4 , 5 , 6 , 7 , 8 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 22 , 23 , 25 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 38 , 39 , 42 , 48 , 49 , 50 , 52 , 56 , 57 , 67 , 68 , 69 , 72 , 73 , 79 , 88 , 89 , 92 , 93 , 94 , 95 , 96 , 98 , 102 , 103 , 105 , 106 , 108 , 110 , 111 , 112 , 114 , 115 , 116 , 117 , 118 , 121 , 122 , 123 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 150 , 152 , 153 , 155 , 156 , 157 , 158 , 159 , 160 , 162 , 163 , 164 , 165 , 166 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 205 , 206 , 209 ) , western blotting ( 3 , 4 , 5 , 6 , 7 , 8 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 22 , 23 , 25 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 38 , 39 , 42 , 48 , 49 , 50 , 52 , 56 , 57 , 67 , 68 , 69 , 72 , 73 , 79 , 88 , 89 , 93 , 94 , 96 , 98 , 102 , 103 , 106 , 108 , 111 , 112 , 114 , 115 , 116 , 117 , 121 , 122 , 123 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 152 , 153 , 155 , 156 , 157 , 158 , 159 , 160 , 162 , 163 , 164 , 165 , 166 , 169 , 170 , 171 , 174 , 175 , 176 , 177 , 178 , 182 , 183 , 185 , 186 , 187 , 191 , 193 , 196 , 198 , 201 , 206 , 208 , 209 )
Disease tissue studied:
ataxia-telangiectasia ( 7 , 106 , 132 , 148 , 166 , 170 , 187 , 193 , 201 , 206 ) , bladder cancer ( 135 , 187 ) , bone cancer ( 19 , 20 , 25 , 34 , 42 , 52 , 67 , 73 , 95 , 98 , 103 , 112 , 130 , 136 , 142 , 147 , 148 , 153 , 156 , 159 , 176 , 180 , 183 , 204 ) , Ewing's sarcoma ( 34 ) , brain cancer ( 13 , 57 , 89 , 183 , 209 , 210 ) , glioblastoma ( 13 , 57 , 89 , 183 , 209 , 210 ) , glioblastoma multiforme ( 13 ) , glioma ( 13 , 57 , 89 , 183 , 209 , 210 ) , breast cancer ( 15 , 37 , 93 , 106 , 110 , 168 , 169 , 171 , 176 , 183 , 208 , 209 ) , breast ductal carcinoma ( 37 ) , HER2 positive breast cancer ( 9 ) , luminal A breast cancer ( 9 ) , luminal B breast cancer ( 9 ) , breast cancer, surrounding tissue ( 9 ) , breast cancer, triple negative ( 9 , 37 ) , cervical cancer ( 39 , 113 , 115 , 195 ) , cervical adenocarcinoma ( 39 , 113 ) , cervical squamous cell carcinoma ( 115 , 195 ) , colorectal cancer ( 8 , 19 , 111 , 132 , 133 , 135 , 144 , 148 , 157 , 171 , 185 , 196 , 206 ) , colorectal carcinoma ( 8 , 19 , 111 , 132 , 133 , 135 , 144 , 148 , 157 , 171 , 185 , 196 , 206 ) , gastric cancer ( 59 ) , HNSCC ( 3 ) , leukemia ( 5 , 66 , 114 , 129 ) , acute myelogenous leukemia ( 66 , 129 ) , chronic lymphocytic leukemia ( 5 ) , T cell leukemia ( 114 ) , liver cancer ( 31 , 201 ) , hepatocellular carcinoma ( 31 ) , lung cancer ( 4 , 7 , 33 , 43 , 44 , 46 , 47 , 55 , 62 , 72 , 145 , 162 , 168 , 169 , 174 , 194 , 196 , 206 ) , non-small cell lung cancer ( 4 , 7 , 43 , 44 , 46 , 53 , 54 , 58 , 60 , 61 , 62 , 145 , 174 , 194 , 196 , 206 ) , non-small cell lung adenocarcinoma ( 4 , 7 , 43 , 44 , 46 , 47 , 54 , 55 , 145 ) , non-small cell large cell lung carcinoma ( 43 ) , non-small cell squamous cell lung carcinoma ( 61 ) , lymphoma ( 33 ) , neuroblastoma ( 128 , 182 ) , ovarian cancer ( 6 , 19 , 68 , 208 ) , pancreatic cancer ( 8 , 14 , 19 , 146 , 171 ) , pancreatic carcinoma ( 8 , 14 , 19 , 146 , 171 ) , prostate cancer ( 17 , 108 , 137 , 164 , 168 , 171 , 175 , 177 , 178 ) , melanoma skin cancer ( 26 ) , fibrosarcoma of soft tissue ( 135 ) , cancer, squamous cell carcinoma ( 7 , 35 , 169 ) , testicular cancer ( 49 , 187 ) , MADA ( 140 ) , Nijmegen Breakage Syndrome ( 132 ) , Xeroderma pigmentosum ( 56 )
Relevant cell line - cell type - tissue:
'stem, mesenchymal' ( 69 ) , 22Rv1 (prostate cell) ( 171 ) , 293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 99 ) , 293 (epithelial) ( 48 , 88 , 147 , 157 , 158 ) , 3T3 (fibroblast) ( 122 , 134 ) , A172 (glial) ( 13 ) , A2780 (ovarian) ( 19 , 199 ) , A549 (pulmonary) ( 4 , 55 , 58 , 162 , 168 , 169 ) , AG01522 (fibroblast) ( 126 ) , Aspc1 (pancreatic) ( 19 ) , AT1ABR (lymphoblastoid) ( 193 ) , AT22IJE-T (fibroblast) ( 166 ) , AT5BI (fibroblast) ( 170 ) , AT5BIVA (fibroblast) ( 7 ) , ATLD2 (fibroblast) ( 132 ) , B lymphocyte-spleen ( 186 ) , BJ (fibroblast) ( 98 ) , bone marrow ( 187 ) , breast ( 9 , 37 ) , BT (epithelial) ( 193 ) , BxPC-3 (pancreatic) ( 146 ) , C3ABR (lymphoblastoid) ( 193 ) , Cal-12T (pulmonary) ( 46 ) , Calu 6 (pulmonary) ( 62 ) , Calu-1 (squamous) ( 171 ) , Capan1 (pancreatic) ( 14 , 146 ) , CCRF-CEM (T lymphocyte) ( 114 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 210 ) , CLBL-1 ( 33 ) , colon ( 189 ) , COS (fibroblast) ( 39 ) , DLD1 (intestinal) ( 135 , 185 ) , DMS153 (pulmonary) ( 44 ) , DU 145 (prostate cell) ( 17 , 164 , 168 ) , dysplastic nevus ( 189 ) , EC155 (T lymphocyte) ( 184 ) , EHEB (B lymphocyte) ( 5 ) , embryo ( 141 ) , ES (stem) ( 96 , 192 , 204 ) , ES (stem) [H2AX (mouse), homozygous knockout] ( 96 ) , ES8 ( 34 ) , FaDu (squamous) ( 169 ) , fibroblast ( 140 , 163 , 187 ) , fibroblast-embryo ( 121 ) , fibroblast-foreskin ( 148 ) , FT/pEBS7 (fibroblast) ( 183 ) , germ cell-testis ( 49 ) , GM00130 (B lymphocyte) ( 101 ) , GM00536 (lymphoblast) ( 206 ) , GM00637 (lymphoblast) ( 132 ) , GM01526 (lymphoblast) ( 148 , 187 , 199 , 206 ) , GM02254 (lymphoblast) ( 199 ) , GM03189 (lymphoblastoid) ( 170 , 201 ) , GM03798 (lymphoblastoid) ( 201 ) , GM04390 (fibroblast) ( 201 ) , HaCaT (keratinocyte) ( 147 ) , HCC1419 (breast cell) ( 183 ) , HCC1937 (breast cell) ( 176 , 197 ) , HCC2279 (pulmonary) ( 145 ) , HCC44 (pulmonary) ( 46 ) , HCC78 (pulmonary) ( 43 ) , HCT116 (intestinal) ( 111 , 132 , 133 , 135 , 144 , 148 , 157 , 173 , 196 , 206 ) , HCT15 (intestinal) ( 8 ) , heart ( 165 ) , HEK293T (epithelial) ( 106 , 117 , 136 , 143 , 154 , 155 , 156 , 187 , 197 ) , HeLa (cervical) ( 12 , 22 , 27 , 36 , 38 , 50 , 73 , 75 , 76 , 77 , 78 , 85 , 88 , 94 , 95 , 98 , 102 , 105 , 106 , 114 , 116 , 118 , 123 , 136 , 138 , 139 , 141 , 142 , 155 , 158 , 166 , 168 , 171 , 183 , 185 , 189 , 191 , 201 , 210 ) , HeLa S3 (cervical) ( 39 , 82 , 113 ) , hematopoietic progenitor-bone marrow ( 79 ) , Hep 3B2.1-7 (hepatic) ( 31 ) , hepatocyte-liver ( 127 ) , HepG2 (hepatic) ( 31 , 201 ) , HFFF-2 (fibroblast) ( 181 ) , HL60 (myeloid) ( 168 , 202 , 205 , 208 ) , HMEC (endothelial) ( 151 ) , HOP62 (pulmonary) ( 62 ) , Hs 578T (breast cell) ( 183 ) , HT-29 (intestinal) ( 132 ) , HT1080 (fibroblast) ( 135 ) , HT116 ( 52 ) , HUES-9 ('stem, embryonic') ( 84 ) , HUVEC (endothelial) ( 135 ) , JB (epithelial) ( 188 ) , Jurkat (T lymphocyte) ( 64 , 80 , 81 , 83 , 88 , 90 , 91 , 97 , 104 , 168 , 208 ) , KB (squamous) ( 115 ) , keratinocyte ( 147 ) , KG-1 (myeloid) ( 66 ) , liver ( 210 ) , LN18 (glial) ( 13 ) , LN229 (glial) ( 13 ) , LNCaP (prostate cell) ( 108 , 137 , 175 , 178 ) , lung ( 43 , 44 , 46 , 47 , 168 , 189 ) , lymphoblastoid ( 163 , 170 ) , lymphocyte ( 132 ) , M059J (glial) ( 57 , 183 ) , M059K (glial) ( 89 ) , MCF-7 (breast cell) ( 15 , 93 , 106 , 110 , 152 , 168 , 171 , 184 , 197 , 208 , 209 ) , MCF10A1 (epithelial) ( 18 ) , MDA-MB-231 (breast cell) ( 169 ) , MEF (fibroblast) ( 22 , 132 , 163 , 180 , 201 ) , MIA PaCa-2 (pancreatic) ( 171 ) , MKN-45 (gastric) ( 59 , 124 , 125 ) , MRC5 (fibroblast) ( 7 , 57 , 98 , 135 , 174 ) , myoblast ( 198 ) , myocyte ( 198 ) , NCI-H1299 (pulmonary) ( 194 , 196 , 206 ) , NCI-H1437 (pulmonary) ( 44 , 46 ) , NCI-H1648 (pulmonary) ( 62 ) , NCI-H1666 (pulmonary) ( 46 ) , NCI-H1703 (squamous) ( 61 ) , NCI-H1781 (pulmonary) ( 43 ) , NCI-H1975 (pulmonary) ( 7 ) , NCI-H2030 (pulmonary) ( 4 ) , NCI-H2073 (pulmonary) ( 44 ) , NCI-H209 (pulmonary) ( 44 ) , NCI-H2228 (pulmonary) ( 43 , 54 ) , NCI-H2405 (pulmonary) ( 46 ) , NCI-H292 (pulmonary) ( 72 ) , NCI-H3122 (pulmonary) ( 43 , 53 ) , NCI-H322 (pulmonary) ( 62 ) , NCI-H3255 (pulmonary) ( 60 ) , NCI-H358 (pulmonary) ( 174 ) , NCI-H520 (squamous) ( 62 ) , NCI-H661 (pulmonary) ( 43 ) , NCI-H838 (pulmonary) ( 44 ) , NCI/ADR-RES (ovarian) ( 208 ) , NHBE (epithelial) ( 174 ) , OCI/AML3 (myeloid) ( 129 ) , OKF4 (epithelial) ( 35 ) , OVCAR3 (ovarian) ( 68 , 181 ) , OVCAR8 (ovarian) ( 6 ) , PA-1 (ovarian) ( 181 ) , Pa-4 (salivary gland) ( 183 ) , PANC-1 (pancreatic) ( 14 ) , PC3 (prostate cell) ( 108 , 177 , 178 , 200 ) , PC9 (pulmonary) ( 62 ) , PCI13 ( 3 ) , prostate ( 92 ) , PSNF5 (fibroblast) ( 150 ) , PSNG13 (fibroblast) ( 150 ) , RKO (intestinal) ( 206 ) , Saos-2 (bone cell) ( 73 , 189 ) , SF268 (glial) ( 209 , 210 ) , SH-SY5Y (neural crest) ( 128 , 182 ) , SiHa (squamous) ( 195 ) , SKBr3 (breast cell) ( 171 ) , skin ( 189 ) , SKOV-3 (ovarian) ( 68 , 181 ) , Su.86.86 (pancreatic) ( 8 ) , SV40 ( 190 ) , SW480 (intestinal) ( 133 , 171 ) , SW620 (intestinal) ( 19 , 171 ) , T-CAM2 (testicular) ( 49 ) , T24 (bladder cell) ( 135 , 187 ) , testis ( 187 ) , TK6 (lymphoblastoid) ( 168 ) , U2OS (bone cell) [GR (human)] ( 197 , 204 ) , U2OS (bone cell) ( 19 , 20 , 25 , 42 , 52 , 67 , 73 , 95 , 98 , 103 , 112 , 130 , 136 , 142 , 147 , 148 , 153 , 156 , 159 , 176 , 180 , 183 ) , U87MG (glial) ( 13 ) , UMSCC1 (squamous) ( 7 ) , UMSCC11B (squamous) ( 35 ) , UMSCC38 (squamous) ( 35 ) , V79 (fibroblast) ( 203 ) , WM239A (melanocyte) ( 26 ) , XP30RO (fibroblast) [POLH (human), transfection] ( 56 ) , XPC (fibroblast) ( 172 ) , YZ5 ( 183 )

Upstream Regulation
Regulatory protein:
AML2 (human) ( 103 ) , APAF (human) ( 29 ) , APC (human) ( 133 ) , Artemis (human) ( 157 ) , ATM (human) ( 86 , 105 , 156 , 163 ) , ATR (human) ( 86 , 156 , 158 , 163 , 183 ) , ATR (mouse) ( 121 ) , Bcl-xL (human) ( 29 ) , BCR-ABL1 (human) ( 79 ) , BID (human) ( 29 ) , BLM (human) ( 150 ) , BRCA1 (human) ( 30 , 118 ) , CAD (human) ( 29 ) , CCDC6 (human) ( 49 ) , CCNA1 (human) ( 19 ) , CCNB1 (human) ( 94 ) , CD45 (human) ( 111 ) , CDC7 (human) ( 14 ) , CDK1 (human) ( 105 ) , Chk1 (human) ( 86 , 111 ) , Chk2 (human) ( 185 ) , CK2A1 (human) ( 89 ) , CLK2 (human) ( 123 ) , DEK (human) ( 73 ) , DFFA (mouse) ( 208 ) , DNAPK (human) ( 86 ) , DNASE1 (human) ( 208 ) , ERK1 (human) ( 93 ) , ERK2 (human) ( 93 ) , FAAP24 (human) ( 123 ) , FANCD2 (human) ( 25 ) , FANCI (human) ( 156 ) , FANCM (human) ( 123 ) , Geminin (human) ( 196 ) , H2AX (human) ( 132 ) , H3F3A (human) ( 171 ) , H4 (human) ( 171 ) , HMGA2 (human) ( 183 ) , HSP90A (human) ( 7 ) , IkB-alpha (human) ( 105 ) , lamin A/C (human) ( 140 ) , MCT1 (human) ( 184 ) , MDC1 (human) ( 180 ) , MDM2 (human) ( 153 ) , MRE11A (human) ( 132 ) , NBS1 (human) ( 163 ) , NKX3-1 (human) ( 108 ) , NPM1 (human) ( 95 ) , p16-INK4A iso4 (human) ( 174 ) , p21Cip1 (human) ( 111 ) , P38A (human) ( 105 ) , p53 (human) ( 105 , 144 ) , PIN1 (human) ( 38 ) , PINX1 (human) ( 38 ) , PML (human) ( 105 ) , POLH (human) ( 56 ) , POLK (human) ( 13 ) , PPP2CA (human) ( 130 , 136 , 158 ) , PPP2CB (human) ( 158 ) , PPP4C (human) ( 130 , 136 ) , PPP4R1 (human) ( 136 ) , PPP4R2 (human) ( 136 ) , RAD51 (human) ( 144 ) , RNF8 (human) ( 95 ) , senataxin (human) ( 30 ) , SMEK1 (human) ( 136 ) , SMEK2 (human) ( 136 ) , SUV39H1 (human) ( 134 ) , SUV39H2 (human) ( 134 ) , TELO2 (human) ( 86 ) , TERT (human) ( 38 ) , TICRR (human) ( 112 ) , TIF1B (human) ( 134 ) , Tip60 (human) ( 174 ) , TOB1 (human) ( 15 ) , TOPBP1 (human) ( 105 ) , TRF1 (human) ( 38 ) , UBE2N (human) ( 95 ) , vpr p15 (retrovirus) ( 114 , 158 ) , WSTF (human) ( 122 ) , XPA (human) ( 172 ) , XPC (human) ( 172 ) , YAP1 (human) ( 16 )
Putative in vivo kinases:
ATM (human) ( 23 ) , DNAPK (human) ( 102 ) , MST1 (human) ( 88 )
Kinases, in vitro:
DNAPK (human) ( 102 , 143 ) , MST1 (human) ( 88 )
Putative upstream phosphatases:
PPM1D (human) ( 106 )
Phosphatases, in vitro:
PPM1D (human) ( 106 , 167 ) , PPP2CA (human) ( 130 , 136 ) , PPP4C (human) ( 130 , 136 )
Treatments:
1R-Chl ( 171 ) , 4-HT ( 18 , 23 , 79 ) , 4-nitroquinoline_1-oxide ( 86 , 203 ) , 7-Chl ( 171 ) , ABT-737 ( 29 ) , adriamycin ( 67 , 92 , 103 , 148 , 153 , 159 , 177 , 183 , 193 , 201 , 203 , 206 ) , alvocidib ( 144 ) , aminothiazole_compound_25 ( 199 ) , anti-Fas ( 208 ) , aphidicolin ( 121 ) , arsenite ( 191 ) , AZD1775 ( 3 , 4 ) , AZD7762 ( 20 ) , BEL ( 148 ) , beta-lapachone ( 149 ) , BIBX ( 169 ) , bleomycin ( 203 ) , BSO ( 168 ) , C-1027 ( 160 ) , caffeine ( 42 , 116 , 142 , 162 , 164 , 183 ) , camptothecin ( 73 , 86 , 92 , 94 , 133 , 159 , 205 ) , captorpil ( 151 ) , carboplatin ( 56 ) , cigarette_smoke ( 162 ) , cisplatin ( 4 , 56 , 69 , 92 , 131 , 159 ) , CK2_activator ( 68 ) , CK2_inhibitor ( 68 ) , compound_C ( 67 ) , DSBs ( 57 , 152 ) , eeyarestatin_1 ( 33 ) , EGTA ( 208 ) , Et743 ( 12 , 132 ) , etoposide ( 73 , 88 , 92 , 93 , 115 , 142 , 143 , 166 , 195 , 203 , 208 ) , Fas ( 29 ) , galiellalactone ( 17 ) , glucose_starvation ( 206 ) , Go_6976 ( 111 , 141 , 166 ) , grape_seed_extract ( 164 , 175 ) , H2O2 ( 49 , 203 , 210 ) , HAMNO ( 35 ) , heating ( 194 ) , HXDV ( 115 ) , hydroxyurea ( 27 , 42 , 52 , 73 , 86 , 111 , 114 , 158 , 163 , 166 , 170 ) , hypertonic_buffer ( 206 ) , hypoxia ( 206 ) , ionizing_radiation ( 48 , 69 , 86 , 92 , 96 , 98 , 101 , 102 , 106 , 111 , 117 , 118 , 121 , 122 , 126 , 129 , 130 , 134 , 135 , 136 , 140 , 141 , 142 , 145 , 151 , 155 , 157 , 163 , 169 , 172 , 176 , 180 , 184 , 187 , 189 , 190 , 194 , 197 , 198 , 203 , 209 , 210 ) , ischemia ( 37 ) , ischemia/reperfusion ( 165 ) , KU-55933 ( 23 , 32 , 57 , 69 , 98 , 121 , 132 , 134 , 149 , 163 , 180 ) , low_pH ( 205 , 206 ) , lurbinectedin ( 12 ) , LY294002 ( 135 , 169 ) , mesna ( 151 ) , MG132 ( 95 ) , MI-63 ( 131 ) , mitomycin_C ( 108 ) , MMS ( 86 ) , NaB ( 32 ) , NAC ( 151 , 168 , 193 ) , neocarzinostatin ( 89 , 134 ) , nocodazole ( 113 , 158 , 201 ) , NSC348884 ( 137 ) , NU7026 ( 57 , 121 , 149 , 162 , 180 , 183 ) , NU7441 ( 23 , 69 , 98 , 132 ) , nutlin-3 ( 131 ) , olaparib ( 34 ) , olomoucine ( 199 ) , PD166285 ( 19 ) , phorbol_ester ( 32 ) , PI-103 ( 135 ) , pifithrin-alpha ( 105 ) , propargylamine ( 182 ) , Q-VD-OPh ( 29 ) , rapamycin ( 105 ) , rasagiline ( 182 ) , SB203580 ( 105 ) , SB218078 ( 28 ) , selenite ( 178 , 202 ) , seliciclib ( 105 , 123 , 199 ) , serum ( 182 ) , serum_starvation ( 206 ) , silibinin ( 177 , 188 ) , silymarin ( 177 ) , siRNA ( 122 , 123 , 130 , 133 , 144 , 153 , 157 , 176 , 183 , 196 ) , SJG-136 ( 173 ) , SN-38 ( 144 ) , sorbitol ( 206 ) , staurosporine ( 208 ) , T-oligo ( 128 ) , taxol ( 191 ) , TBB ( 142 ) , teriflunomide ( 2 ) , thymidine ( 111 ) , tirapazamine ( 195 , 203 ) , TMZ removal ( 13 ) , topotecan ( 179 ) , triphala ( 146 ) , UCN-01 ( 208 ) , UV ( 86 , 106 , 108 , 114 , 147 , 163 , 172 , 188 , 197 ) , VE-821 ( 20 ) , virus infection ( 116 , 127 ) , VM-26 ( 202 , 205 ) , vorinostat ( 3 ) , wortmannin ( 57 , 116 , 142 , 172 , 184 ) , WR1065 ( 151 ) , WR255591 ( 151 ) , WR2721 ( 151 ) , WR33278 ( 151 ) , Y27632 ( 147 ) , Z-VAD-FMK ( 105 , 115 , 208 )

Downstream Regulation
Effects of modification on H2AX:
intracellular localization ( 22 , 93 , 126 , 130 , 180 ) , molecular association, regulation ( 22 , 102 , 180 , 204 , 207 )
Effects of modification on biological processes:
apoptosis, altered ( 88 ) , cell cycle regulation ( 69 , 207 ) , cytoskeletal reorganization ( 143 ) , DNA repair, altered ( 96 ) , DNA repair, induced ( 22 )
Induce interaction with:
53BP1 (human) ( 204 ) , MDC1 (human) ( 180 , 207 ) , NBS1 (human) ( 180 ) , PARP1 (human) ( 180 ) , RAD50 (human) ( 180 )
Inhibit interaction with:
H1B (human) ( 102 )

Disease / Diagnostics Relevance
Relevant diseases:
Bloom's syndrome ( 150 ) , hepatocellular carcinoma ( 31 ) , testicular cancer ( 187 )

References 

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Glanzer JG, et al. (2014) RPA inhibition increases replication stress and suppresses tumor growth. Cancer Res 74, 5165-72
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36

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
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37

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
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38

Yoo JE, Park YN, Oh BK (2014) PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles. J Biol Chem 289, 6886-98
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39

Kubota S, et al. (2014) Activation of the Prereplication Complex Is Blocked by Mimosine through Reactive Oxygen Species-activated Ataxia Telangiectasia Mutated (ATM) Protein without DNA Damage. J Biol Chem 289, 5730-46
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Ullal AV, et al. (2014) Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates. Sci Transl Med 6, 219ra9
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Sone K, et al. (2014) Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair. Nat Commun 5, 5691
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Toledo LI, et al. (2013) ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA. Cell 155, 1088-103
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43

Rikova K, Hall B (2013) CST Curation Set: 20740, 21167, 30170, 30171, 30172; Year: 2013; Biosample/Treatment: cell line, H2228, H3122, HCC78, H661, H1781; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

44

Rikova K, Hall B (2013) CST Curation Set: 20742, 21169, 30176, 30177, 30178; Year: 2013; Biosample/Treatment: cell line, H838, DMS153, H2073, H209, H1437; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

45

Bitomsky N, et al. (2013) Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. Proc Natl Acad Sci U S A 110, E4203-12
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46

Rikova K, Hall B (2013) CST Curation Set: 20741, 21168, 30173, 30174, 30175; Year: 2013; Biosample/Treatment: cell line, H1666, CAL-12T, H2405, HCC44, H1437; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

47

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
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48

Reuven N, Adler J, Meltser V, Shaul Y (2013) The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ 20, 1330-40
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49

Staibano S, et al. (2013) Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors. BMC Cancer 13, 433
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50

Boohaker RJ, Cui X, Stackhouse M, Xu B (2013) ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity. Radiother Oncol 108, 403-8
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51

Yang X, et al. (2013) Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover. J Biol Chem 288, 18271-82
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52

Hughes BT, et al. (2013) Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation. Proc Natl Acad Sci U S A 110, 8954-9
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53

Rikova K (2013) CST Curation Set: 18503; Year: 2013; Biosample/Treatment: cell line, H3122/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSQ, p[ST]QG Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607 Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966
Curated Info

54

Rikova K (2013) CST Curation Set: 18502; Year: 2013; Biosample/Treatment: cell line, H2228/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSQ, p[ST]QG Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607 Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966
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55

Johnson H, Lescarbeau RS, Gutierrez JA, White FM (2013) Phosphotyrosine profiling of NSCLC cells in response to EGF and HGF reveals network specific mediators of invasion. J Proteome Res 12, 1856-67
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56

Sokol AM, Cruet-Hennequart S, Pasero P, Carty MP (2013) DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells. Sci Rep 3, 3277
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57

Kotula E, et al. (2013) DNA-PK Target Identification Reveals Novel Links between DNA Repair Signaling and Cytoskeletal Regulation. PLoS One 8, e80313
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58

Rikova K (2012) CST Curation Set: 16148; Year: 2012; Biosample/Treatment: cell line, A549/iressa, gleevec, crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSQ, p[ST]QG Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607 Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966
Curated Info

59

Rikova K (2012) CST Curation Set: 16145; Year: 2012; Biosample/Treatment: cell line, MKN45/crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSQ, p[ST]QG Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607 Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966
Curated Info

60

Rikova K (2012) CST Curation Set: 16146; Year: 2012; Biosample/Treatment: cell line, H3255/iressa; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSQ, p[ST]QG Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607 Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966
Curated Info

61

Rikova K (2012) CST Curation Set: 16147; Year: 2012; Biosample/Treatment: cell line, H1703/gleevec; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pSQ, p[ST]QG Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607 Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966
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62

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Mulhern D (2012) CST Curation Set: 14049; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q
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65

White D, et al. (2012) The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation. Mol Cancer Res 10, 401-14
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Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56
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Rajeshkumar NV, et al. (2011) MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts. Clin Cancer Res 17, 2799-806
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Zhou J (2011) CST Curation Set: 11707; Year: 2011; Biosample/Treatment: cell line, HeLa/UV; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966, PTMScan(R) Phospho-ATM/ATR Substrate Motif (S*/T*QG) Immunoaffinity Beads Cat#: 6969
Curated Info

76

Zhou J (2011) CST Curation Set: 11708; Year: 2011; Biosample/Treatment: cell line, HeLa/UV; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) ATM/ATR Substrate (S*/T*QG) (P-S/T2-100) Rabbit mAb Cat#: 6966, PTMScan(R) Phospho-ATM/ATR Substrate Motif (S*/T*QG) Immunoaffinity Beads Cat#: 6969
Curated Info

77

Zhou J (2011) CST Curation Set: 11709; Year: 2011; Biosample/Treatment: cell line, HeLa/UV; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607, PTMScan(R) Phospho-ATM/ATR Substrate (S*Q) Immunoaffinity Beads Cat#: 9884
Curated Info

78

Zhou J (2011) CST Curation Set: 11710; Year: 2011; Biosample/Treatment: cell line, HeLa/UV; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho-ATM/ATR Substrate (S*Q) (D23H2/D69H5) Rabbit mAb Cat#: 9607, PTMScan(R) Phospho-ATM/ATR Substrate (S*Q) Immunoaffinity Beads Cat#: 9884
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79

Altman BJ, et al. (2011) Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. Oncogene 30, 1855-67
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Guo A (2011) CST Curation Set: 11634; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
Curated Info

81

Guo A (2011) CST Curation Set: 11376; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q
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82

Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457
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Guo A (2011) CST Curation Set: 11116; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
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Possemato A (2010) CST Curation Set: 10867; Year: 2010; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M)
Curated Info

91

Possemato A (2010) CST Curation Set: 10868; Year: 2010; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M)
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92

Jäämaa S, et al. (2010) DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue. Cancer Res 70, 8630-41
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Wei F, Xie Y, Tao L, Tang D (2010) Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation. Cell Signal 22, 1783-9
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Kreis NN, et al. (2010) Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells. Oncogene 29, 5591-603
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Possemato A (2010) CST Curation Set: 10303; Year: 2010; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
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Giunta S, Belotserkovskaya R, Jackson SP (2010) DNA damage signaling in response to double-strand breaks during mitosis. J Cell Biol 190, 197-207
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Jiang X, Xu Y, Price BD (2010) Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway. FEBS Lett 584, 2926-30
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Li A, et al. (2010) Phosphorylation of Histone H2A.X by DNA-dependent Protein Kinase Is Not Affected by Core Histone Acetylation, but It Alters Nucleosome Stability and Histone H1 Binding. J Biol Chem 285, 17778-88
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Possemato A (2010) CST Curation Set: 9637; Year: 2010; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
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Guo A (2008) CST Curation Set: 5568; Year: 2008; Biosample/Treatment: cell line, MKN-45/Su11274; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
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125

Guo A (2008) CST Curation Set: 5569; Year: 2008; Biosample/Treatment: cell line, MKN-45/Su11274; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
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Zhou J (2008) CST Curation Set: 4706; Year: 2008; Biosample/Treatment: cell line, HeLa/untreated; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q Antibodies Used to Purify Peptides prior to LCMS: Phospho(Ser/Thr) ATM/ATR Substrate Antibody (polyAB) Cat#: 3005, PTMScan(R) Phospho-ATM/ATR Substrate Motif (pS/pTQ) Immunoaffinity Beads Cat#: 1980
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