Thr165
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Home > Phosphorylation Site Page: > Thr165  -  NEK3 (human)

Site Information
FACTYVGtPYYVPPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 57829902

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , MCF-7 (breast cell) ( 1 ) , T47D (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )
Kinases, in vitro:
NEK3 (human) ( 1 )
Treatments:
PRL ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on NEK3:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
cell adhesion, altered ( 1 ) , cell motility, induced ( 1 )

References 

1

Harrington KM, Clevenger CV (2016) Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration. J Biol Chem 291, 21388-21406
27489110   Curated Info

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