Lys259

Site Information
EEGLCAPkKRRTEEK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 57676500

In vivo Characterization
Methods used to characterize site in vivo:	immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	bone cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:	A549 (pulmonary) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , U2OS (bone cell) ( 1 )

Downstream Regulation
Effects of modification on DGCR8:	intracellular localization ( 1 )
Effects of modification on biological processes:	carcinogenesis, inhibited ( 1 ) , cell growth, inhibited ( 1 )

References
1	Zhu C, et al. (2016) K259-SUMOylation of DGCR8 promoted by p14ARF exerts a tumor-suppressive function. J Mol Cell Biol 27436753 Curated Info