Tyr516

Site Information
PVIENPQyFGITNSQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448813

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:	lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:	'neuron, cortical'-brain ( 1 ) , NCI-H460 (pulmonary) ( 2 )

Upstream Regulation
Kinases, in vitro:	TrkB (human) ( 1 )
Treatments:	2-deoxyglucose ( 2 )

References
1	Huang YZ, McNamara JO (2010) Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. J Biol Chem 285, 8207-17 20064930 Curated Info
2	Zhong D, et al. (2009) The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R. J Biol Chem 284, 23225-33 19574224 Curated Info