Tyr706
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Home > Phosphorylation Site Page: > Tyr706  -  TrkB (mouse)

Site Information
DVysTDyyRVGGHtM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448812

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 , 6 ) , mass spectrometry ( 7 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 8 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 , 8 )
Disease tissue studied:
liver cancer ( 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 8 ) , 'brain, cerebellum' ( 1 ) , 'brain, cerebral cortex' ( 3 ) , 'brain, embryonic' ( 7 ) , 'brain, hippocampus' ( 2 ) , 'neuron, cortical' ( 3 ) , 'neuron, cortical'-brain ( 6 ) , 'neuron, ventral tegmental'-spinal cord ( 5 ) , HepG2 (hepatic) ( 4 )

Upstream Regulation
Regulatory protein:
Calnexin (human) ( 3 ) , CDKL5 (human) ( 2 ) , MECP2 (human) ( 1 )
Treatments:
1Na-PP1 ( 6 ) , BDNF ( 1 , 3 , 5 , 6 ) , CPT-157633 ( 1 ) , morphine ( 8 ) , neurotrophin-3 ( 4 ) , PP1 ( 6 ) , selectritinib ( 4 ) , Zn(2+) ( 6 )

Downstream Regulation
Effects of modification on TrkB:
activity, induced ( 1 )
Effects of modification on biological processes:
neural plasticity ( 2 )

References 

1

Xu FX, et al. (2023) Purkinje-cell-specific MeCP2 deficiency leads to motor deficits and autistic-like behavior due to aberrations in PTP1B-TrkB-SK signaling. Cell Rep 42, 113559
38100348   Curated Info

2

Zhu ZA, et al. (2023) CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling. Cell Rep 42, 113202
37777961   Curated Info

3

Lüningschrör P, et al. (2023) Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development. Dev Cell 58, 1733-1747.e6
37506696   Curated Info

4

Trinh VQ, et al. (2023) Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation. Sci Signal 16, eadf6696
37253090   Curated Info

5

Dombert B, et al. (2017) BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221). Front Mol Neurosci 10, 346
29163025   Curated Info

6

Huang YZ, McNamara JO (2010) Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. J Biol Chem 285, 8207-17
20064930   Curated Info

7

Guo A (2007) CST Curation Set: 2672; Year: 2007; Biosample/Treatment: tissue, brain/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

8

Lucas G, et al. (2003) Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia. Nat Neurosci 6, 221-2
12601381   Curated Info