Tyr705

Site Information
RDVysTDyyRVGGHt SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448811

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 , 5 ) , mass spectrometry ( 6 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 7 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 7 )
Disease tissue studied:	liver cancer ( 2 )
Relevant cell line - cell type - tissue:	'brain, brainstem' ( 7 ) , 'brain, cerebral cortex' ( 1 ) , 'neuron, cortical' ( 1 ) , 'neuron, cortical'-brain ( 5 ) , 'neuron, ventral tegmental'-spinal cord ( 4 ) , brain ( 6 ) , HepG2 (hepatic) ( 2 ) , retinal-retina ( 3 )

Upstream Regulation
Regulatory protein:	Calnexin (human) ( 1 )
Treatments:	1Na-PP1 ( 5 ) , 7, 8-Dihydroxyflavone ( 3 ) , BDNF ( 1 , 4 , 5 ) , morphine ( 7 ) , neurotrophin-3 ( 2 ) , PP1 ( 5 ) , selectritinib ( 2 ) , Zn(2+) ( 5 )

References
1	Lüningschrör P, et al. (2023) Calnexin controls TrkB cell surface transport and ER-phagy in mouse cerebral cortex development. Dev Cell 58, 1733-1747.e6 37506696 Curated Info
2	Trinh VQ, et al. (2023) Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation. Sci Signal 16, eadf6696 37253090 Curated Info
3	Zaitoun IS, et al. (2021) 7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy. PLoS One 16, e0260793 34855884 Curated Info
4	Dombert B, et al. (2017) BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221). Front Mol Neurosci 10, 346 29163025 Curated Info
5	Huang YZ, McNamara JO (2010) Mutual regulation of Src family kinases and the neurotrophin receptor TrkB. J Biol Chem 285, 8207-17 20064930 Curated Info
6	Guo A (2007) CST Curation Set: 2675; Year: 2007; Biosample/Treatment: tissue, brain/LY; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
7	Lucas G, et al. (2003) Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia. Nat Neurosci 6, 221-2 12601381 Curated Info