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Site Information |
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RFVGRRQsLIQDARK SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448545 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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References | |
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Zhang H, et al. (2014) Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser(19) and Ser (40) phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells. Naunyn Schmiedebergs Arch Pharmacol 387, 15-22
24043291 Curated Info |
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Bobrovskaya L, et al. (2007) Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis. J Neurochem 100, 479-89
17064352 Curated Info |
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Lehmann IT, et al. (2006) Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation. J Biol Chem 281, 17644-51
16644734 Curated Info |
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Bobrovskaya L, Dunkley PR, Dickson PW (2004) Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells. J Neurochem 90, 857-64
15287891 Curated Info |
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Cammarota M, Bevilaqua LR, Rostas JA, Dunkley PR (2003) Histamine activates tyrosine hydroxylase in bovine adrenal chromaffin cells through a pathway that involves ERK1/2 but not p38 or JNK. J Neurochem 84, 453-8
12558965 Curated Info |
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Bobrovskaya L, Odell A, Leal RB, Dunkley PR (2001) Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation. J Neurochem 78, 490-8
11483651 Curated Info |
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Kleppe R, Toska K, Haavik J (2001) Interaction of phosphorylated tyrosine hydroxylase with 14-3-3 proteins: evidence for a phosphoserine 40-dependent association. J Neurochem 77, 1097-107
11359875 Curated Info |