Ser31
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser31  -  TH (cow)

Site Information
KQAEAIMsPRFVGRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448544

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 6 ) , phospho-antibody ( 1 , 2 , 4 , 5 ) , phosphopeptide mapping ( 3 , 4 ) , western blotting ( 1 , 2 , 4 , 5 )
Relevant cell line - cell type - tissue:
adrenal medulla ( 1 ) , BACC (adrenal) ( 4 , 5 ) , chromaffin ( 2 ) , chromaffin-adrenal gland ( 3 , 6 )

Upstream Regulation
Treatments:
angiotensin ( 6 ) , angiotensin_2 ( 2 , 3 ) , anisomycin ( 4 , 6 ) , cAMP_analog ( 1 ) , cimetidine ( 5 ) , colforsin ( 3 , 4 ) , histamine ( 2 , 5 ) , JNK_inhibitor_I ( 5 ) , losartan ( 6 ) , mepyramine ( 5 ) , nicotine ( 2 ) , nobiletin ( 1 ) , PD123319 ( 6 ) , PD98059 ( 6 ) , phorbol_ester ( 2 ) , SB202474 ( 6 ) , SB203580 ( 5 , 6 ) , U0126 ( 5 , 6 )

References 

1

Zhang H, et al. (2014) Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser(19) and Ser (40) phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells. Naunyn Schmiedebergs Arch Pharmacol 387, 15-22
24043291   Curated Info

2

Bobrovskaya L, et al. (2007) Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis. J Neurochem 100, 479-89
17064352   Curated Info

3

Lehmann IT, et al. (2006) Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation. J Biol Chem 281, 17644-51
16644734   Curated Info

4

Bobrovskaya L, Dunkley PR, Dickson PW (2004) Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells. J Neurochem 90, 857-64
15287891   Curated Info

5

Cammarota M, Bevilaqua LR, Rostas JA, Dunkley PR (2003) Histamine activates tyrosine hydroxylase in bovine adrenal chromaffin cells through a pathway that involves ERK1/2 but not p38 or JNK. J Neurochem 84, 453-8
12558965   Curated Info

6

Bobrovskaya L, Odell A, Leal RB, Dunkley PR (2001) Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation. J Neurochem 78, 490-8
11483651   Curated Info