Ser862
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Home > Phosphorylation Site Page: > Ser862  -  GluR4 (rat)

Site Information
TRNKARLsITGSVGE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448810

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 3 , 4 ) , phospho-antibody ( 1 , 3 ) , phosphopeptide mapping ( 4 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 1 , 3 ) , 293 (epithelial) ( 1 ) , HEK293T (epithelial) ( 4 ) , retina ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (rat) ( 1 , 3 , 4 ) , PKCG (human) ( 1 )
Kinases, in vitro:
CAMK2A (human) ( 4 ) , PKACA (human) ( 4 ) , PKCA (human) ( 4 ) , PKCG (rat) ( 2 )
Treatments:
8-Rp-cAMP ( 3 ) , colforsin ( 1 , 3 , 4 ) , IBMX ( 3 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on GluR4:
intracellular localization ( 3 ) , receptor internalization, altered ( 3 )

References 

1

Gomes AR, et al. (2007) PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression. Traffic 8, 259-69
17233759   Curated Info

2

Correia SS, et al. (2003) Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation. J Biol Chem 278, 6307-13
12471040   Curated Info

3

Esteban JA, et al. (2003) PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity. Nat Neurosci 6, 136-43
12536214   Curated Info

4

Carvalho AL, Kameyama K, Huganir RL (1999) Characterization of phosphorylation sites on the glutamate receptor 4 subunit of the AMPA receptors. J Neurosci 19, 4748-54
10366608   Curated Info

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