Thr27
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Home > Phosphorylation Site Page: > Thr27  -  AID (mouse)

Site Information
WAKGRHEtYLCYVVK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471423

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 )
Disease tissue studied:
lymphoma ( 1 ) , B cell lymphoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , B lymphocyte-spleen ( 2 ) , DT40 (B lymphocyte) [AID (mouse)] ( 1 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 2 )

Downstream Regulation
Effects of modification on AID:
enzymatic activity, induced ( 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
chromatin organization, altered ( 1 )
Induce interaction with:
RPA1 (human) ( 2 )

References 

1

Chatterji M, Unniraman S, McBride KM, Schatz DG (2007) Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 179, 5274-80
17911613   Curated Info

2

Basu U, et al. (2005) The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438, 508-11
16251902   Curated Info