Thr27
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr27  -  AID (human)

Site Information
WAKGRREtYLCYVVK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471423

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , flow cytometry ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
B lymphocyte-spleen ( 1 ) , HEK293T (epithelial) ( 3 ) , HeLa (cervical) ( 1 ) , SF9 ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 3 )
Kinases, in vitro:
PKACA (human) ( 3 )
Treatments:
colforsin ( 3 ) , H-89 ( 3 ) , IBMX ( 3 )

Downstream Regulation
Effects of modification on AID:
enzymatic activity, induced ( 3 ) , enzymatic activity, inhibited ( 1 )

References 

1

Demorest ZL, Li M, Harris RS (2011) Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein. J Biol Chem 286, 26568-75
21659520   Curated Info

2

Pham P, et al. (2008) Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase. J Biol Chem 283, 17428-39
18417471   Curated Info

3

Pasqualucci L, Kitaura Y, Gu H, Dalla-Favera R (2006) PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci U S A 103, 395-400
16387847   Curated Info