Lys128

Site Information
RSGFPRDkLAELHGN SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 573777002

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	liver cancer ( 1 ) , liver adenocarcinoma ( 1 ) , hepatocellular carcinoma ( 1 )
Relevant cell line - cell type - tissue:	BEL-7404 ( 1 ) , HCC (hepatic) ( 1 ) , Huh7 (hepatic) ( 1 ) , Jurkat (T lymphocyte) ( 2 ) , SK-HEP-1 (endothelial) ( 1 )

Downstream Regulation
Effects of modification on SIRT6:	protein degradation ( 1 )
Effects of modification on biological processes:	carcinogenesis, induced ( 1 )

References
1	Du L, et al. (2021) USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization. Cancer Res 81, 3822-3834 33903120 Curated Info
2	Udeshi ND, et al. (2013) Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Mol Cell Proteomics 12, 825-31 23266961 Curated Info