Ser280
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Home > Phosphorylation Site Page: > Ser280  -  CIITA (human)

Site Information
TVHGLPTsPDRPGsT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471421

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 3 ) , flow cytometry ( 1 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 1 , 3 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 , 3 ) , ERK2 (human) ( 1 , 3 )
Kinases, in vitro:
ERK1 (human) ( 3 ) , ERK2 (human) ( 3 )
Treatments:
U0126 ( 3 )

Downstream Regulation
Effects of modification on CIITA:
intracellular localization ( 1 ) , molecular association, regulation ( 3 ) , protein degradation ( 3 ) , protein stabilization ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 , 3 )
Induce interaction with:
CCNT1 (human) ( 3 )

References 

1

Morgan JE, et al. (2015) The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination. Biosci Rep 35
26181363   Curated Info

2

Bhat KP, Truax AD, Greer SF (2010) Phosphorylation and ubiquitination of degron proximal residues are essential for class II transactivator (CIITA) transactivation and major histocompatibility class II expression. J Biol Chem 285, 25893-903
20538595   Curated Info

3

Drozina G, Kohoutek J, Nishiya T, Peterlin BM (2006) Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages. J Biol Chem 281, 39963-70
17095509   Curated Info