Ser939
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Home > Phosphorylation Site Page: > Ser939  -  TSC2 (rat)

Site Information
KFRARSTsLNERPKS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448501

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'kidney, cortex' ( 2 ) , 'muscle, skeletal' ( 1 ) , 293 (epithelial) ( 3 ) , myocyte-heart ( 3 )

Upstream Regulation
Kinases, in vitro:
Akt1 (human) ( 3 ) , p90RSK (human) ( 3 )
Treatments:
insulin ( 3 ) , LY294002 ( 3 ) , phorbol_ester ( 3 ) , synergist ablation ( 1 ) , U0126 ( 3 )

References 

1

Lee Hamilton D, et al. (2014) Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. Am J Physiol Endocrinol Metab 307, E365-73
24961241   Curated Info

2

Feric M, et al. (2011) Large-scale phosphoproteomic analysis of membrane proteins in renal proximal and distal tubule. Am J Physiol Cell Physiol 300, C755-70
21209370   Curated Info

3

Rolfe M, McLeod LE, Pratt PF, Proud CG (2005) Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). Biochem J 388, 973-84
15757502   Curated Info

4

Inoki K, et al. (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4, 648-57
12172553   Curated Info