Tyr333
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Home > Phosphorylation Site Page: > Tyr333  -  CTNNB1 (human)

Site Information
NIMRTytyEkLLWTT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471406

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 ) , mass spectrometry ( 4 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 ) , breast cancer ( 1 ) , colorectal cancer ( 3 ) , colorectal carcinoma ( 3 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 ) , pancreatic ductal adenocarcinoma ( 1 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
FBXL7 (human) ( 1 )
Putative in vivo kinases:
Src (human) ( 2 )
Kinases, in vitro:
Brk (human) ( 3 ) , Src (human) ( 2 )
Treatments:
acetaldehyde ( 4 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 2 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 2 ) , cell cycle regulation ( 2 ) , cell growth, induced ( 2 ) , transcription, induced ( 2 )
Induce interaction with:
PKM (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
glioblastoma ( 2 )

References 

1

Moro L, et al. (2020) Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis. Nat Cell Biol
32839549   Curated Info

2

Yang W, et al. (2011) Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature 480, 118-22
22056988   Curated Info

3

Palka-Hamblin HL, et al. (2010) Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci 123, 236-45
20026641   Curated Info

4

Sheth P, et al. (2007) Acetaldehyde dissociates the PTP1B-E-cadherin-beta-catenin complex in Caco-2 cell monolayers by a phosphorylation-dependent mechanism. Biochem J 402, 291-300
17087658   Curated Info