Tyr333
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Home > Phosphorylation Site Page: > Tyr333  -  CTNNB1 (human)

Site Information
NIMRTytyEkLLWTT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471406

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 3 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
brain cancer ( 1 ) , glioblastoma ( 1 ) , glioma ( 1 ) , colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , Caco-2 (intestinal) ( 3 ) , SW620 (intestinal) ( 2 ) , U87MG (glial) [EGFR (human), transfection] ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 1 )
Kinases, in vitro:
Brk (human) ( 2 ) , Src (human) ( 1 )
Treatments:
acetaldehyde ( 3 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
PKM (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
glioblastoma ( 1 )

References 

1

Yang W, et al. (2011) Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature 480, 118-22
22056988   Curated Info

2

Palka-Hamblin HL, et al. (2010) Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci 123, 236-45
20026641   Curated Info

3

Sheth P, et al. (2007) Acetaldehyde dissociates the PTP1B-E-cadherin-beta-catenin complex in Caco-2 cell monolayers by a phosphorylation-dependent mechanism. Biochem J 402, 291-300
17087658   Curated Info