Ser183
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Home > Phosphorylation Site Page: > Ser183  -  IGFBP3 (human)

Site Information
KKGHAKDsQRYKVDy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471397

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
DNAPK (human) ( 1 )

Downstream Regulation
Effects of modification on IGFBP3:
intracellular localization ( 2 )
Effects of modification on biological processes:
apoptosis, altered ( 2 ) , apoptosis, inhibited ( 1 ) , cell growth, induced ( 1 )

References 

1

Zhang Q, Steinle JJ (2013) DNA-PK Phosphorylation of IGFBP-3 Is Required to Prevent Apoptosis in Retinal Endothelial Cells Cultured in High Glucose. Invest Ophthalmol Vis Sci 54, 3052-7
23557743   Curated Info

2

Cobb LJ, Liu B, Lee KW, Cohen P (2006) Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer Res 66, 10878-84
17108124   Curated Info