Ser73
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Home > Phosphorylation Site Page: > Ser73  -  PSD-95 (rat)

Site Information
ITLERGNsGLGFSIA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471390

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoassay ( 1 ) , immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus, CA1 region' ( 1 ) , 'neuron, hippocampal'-brain ( 3 ) , COS (fibroblast) ( 3 ) , neuron-'brain, hippocampus' ( 2 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 1 , 3 )
Kinases, in vitro:
CAMK2A (human) ( 3 )
Treatments:
KN-62 ( 1 ) , KN-93 ( 3 ) , NMDA ( 3 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on PSD-95:
activity, inhibited ( 2 ) , intracellular localization ( 2 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
cell growth, altered ( 2 )
Inhibit interaction with:
NMDAR2A (human) ( 3 )

References 

1

Nowacka A, et al. (2020) PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD. Sci Rep 10, 2054
32029829   Curated Info

2

Steiner P, et al. (2008) Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity. Neuron 60, 788-802
19081375   Curated Info

3

Gardoni F, Polli F, Cattabeni F, Di Luca M (2006) Calcium-calmodulin-dependent protein kinase II phosphorylation modulates PSD-95 binding to NMDA receptors. Eur J Neurosci 24, 2694-704
17156196   Curated Info