Ser188
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Home > Phosphorylation Site Page: > Ser188  -  FRAT1 (human)

Site Information
RLQQRRGsQPETRTG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471366

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Kinases, in vitro:
GSK3B (human) ( 1 ) , PKACA (human) ( 1 ) , PKCA (human) ( 1 )
Treatments:
bryostatin_1 ( 1 ) , cAMP_analog ( 1 ) , colforsin ( 1 ) , lithium ( 1 ) , norepinephrine ( 1 ) , okadaic_acid ( 1 ) , phorbol_ester ( 1 ) , SB415286 ( 1 )

Downstream Regulation
Effects of modification on FRAT1:
activity, inhibited ( 1 ) , protein degradation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Hagen T, et al. (2006) FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. J Biol Chem 281, 35021-9
16982607   Curated Info