Ser675
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Home > Phosphorylation Site Page: > Ser675  -  MLK3 (mouse)

Site Information
LSRERGEsPTAPPPA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448790

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PPP1CA (human) ( 1 ) , PPP1CC (human) ( 1 )
Putative upstream phosphatases:
PPP1CC (human) ( 1 )
Treatments:
insulin ( 1 ) , siRNA ( 1 ) , URMC-099 ( 1 )

Downstream Regulation
Effects of modification on MLK3:
enzymatic activity, inhibited ( 1 )

References 

1

Yadav Y, Sharma M, Dey CS (2023) PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes. Cell Commun Signal 21, 82
37085815   Curated Info