Arg222
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Home > Di-methylation Site Page: > Arg222  -  EGFR (human)

Site Information
CAQQCSGrCrGKSPs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56856900

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HT-29 (intestinal) ( 1 ) , SKCO1 (epithelial) ( 1 ) , SW48 (intestinal) ( 1 )

Downstream Regulation
Effects of modification on EGFR:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 1 )

References 

1

Liao HW, et al. (2015) PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest 125, 4529-43
26571401   Curated Info