Ser147
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Home > Phosphorylation Site Page: > Ser147  -  PBXIP1 (human)

Site Information
REEGRCsssDDDtDV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 471206

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 )
Disease tissue studied:
lung cancer ( 4 ) , non-small cell lung cancer ( 4 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 5 ) , H2077 (pulmonary) ( 4 ) , H322M (pulmonary) ( 4 ) , HeLa (cervical) ( 6 , 7 ) , liver ( 3 ) , NCI-H1395 (pulmonary) ( 4 ) , NCI-H2030 (pulmonary) ( 4 ) , WM239A (epidermal) ( 1 )

Upstream Regulation
Treatments:
estradiol ( 2 )

Downstream Regulation
Effects of modification on PBXIP1:
protein degradation ( 2 )
Effects of modification on biological processes:
transcription, induced ( 2 )

References 

1

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

2

Shostak K, et al. (2014) MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation. Cell Death Differ 21, 811-24
24488098   Curated Info

3

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

4

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

5

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

6

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

7

Olsen JV, et al. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127, 635-48
17081983   Curated Info