Lys64
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Home > Acetylation Site Page: > Lys64  -  LKB1 (human)

Site Information
EGSYGKVkEVLDSET   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56714902

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
'muscle, smooth' ( 1 ) , PPAEC (endothelial) ( 1 )

Downstream Regulation
Effects of modification on LKB1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , cell cycle regulation ( 1 ) , cell growth, altered ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 ) , HERC2 (human) ( 1 ) , SIRT1 (human) ( 1 )
Inhibit interaction with:
STRAD (human) ( 1 )

References 

1

Bai B, et al. (2016) Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. Oncotarget 7, 39065-39081
27259994   Curated Info