Ser194
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Home > Phosphorylation Site Page: > Ser194  -  CLIK1L (human)

Site Information
kVADFGLskVCSASG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56663329

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
breast ( 2 ) , MOLM 13 (myeloid) ( 1 )

Upstream Regulation
Putative upstream phosphatases:
CTDSPL2 (human) ( 1 )
Phosphatases, in vitro:
CTDSPL2 (human) ( 1 )

Downstream Regulation
Effects of modification on CLIK1L:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , cell growth, inhibited ( 1 )

References 

1

Polyanskaya SA, et al. (2022) SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia. Cell Rep 38, 110233
35021089   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

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