Ser103
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Home > Phosphorylation Site Page: > Ser103  -  PRPS1 (human)

Site Information
RQDKKDKsRAPISAK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56655989

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
breast ( 2 ) , HCT116 (intestinal) ( 1 ) , HEK293T (epithelial) ( 1 ) , LoVo (intestinal) ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK1 (human) ( 1 )
Kinases, in vitro:
CDK1 (human) ( 1 )
Treatments:
AMG_900 ( 1 ) , Go_6983 ( 1 ) , H-89 ( 1 ) , Irinotecan ( 1 ) , LY294002 ( 1 ) , MK-2206 ( 1 ) , PD98059 ( 1 ) , PHA793887 ( 1 ) , R547 ( 1 ) , SB216763 ( 1 ) , siRNA ( 1 ) , SNS-032 ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on PRPS1:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell cycle regulation ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
colorectal carcinoma ( 1 )

References 

1

Jing X, et al. (2019) Cell cycle-dependent phosphorylation of PRPS1 fuels nucleotide synthesis and promotes tumorigenesis. Cancer Res
31253668   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

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