Thr749
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Home > Phosphorylation Site Page: > Thr749  -  STAT1 (human)

Site Information
EFDsMMNtV______   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 56654462

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:
breast ( 2 ) , macrophage ( 1 ) , THP1 (myeloid) ( 1 ) , U3A (fibroblast) ( 1 )

Upstream Regulation
Regulatory protein:
IFNAR2 (human) ( 1 ) , MYD88 (human) ( 1 )
Putative in vivo kinases:
IKKB (human) ( 1 )
Treatments:
BMS-345541 ( 1 ) , LPS ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on STAT1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
RNA stability, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 )

References 

1

Metwally H, et al. (2020) Noncanonical STAT1 phosphorylation expands its transcriptional activity into promoting LPS-induced IL-6 and IL-12p40 production. Sci Signal 13
32209697   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info