Ser418

Site Information
GCEGRGLsVHTDMAS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 56649827

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Disease tissue studied:	HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 )
Relevant cell line - cell type - tissue:	breast ( 2 ) , E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 )

Downstream Regulation
Effects of modification on DVL2:	molecular association, regulation ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:	signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:	DVL2 (human) ( 1 )

References
1	Beitia GJ, et al. (2021) Regulation of Dishevelled DEP domain swapping by conserved phosphorylation sites. Proc Natl Acad Sci U S A 118 34155117 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info